Erciyes University - Info Package

Course unit title	Level of course unit	Course unit code	Type of course unit	Semester of course unit	Local credit	ECTS credit	Syllabus
DRUG ANALYSISIN BIOLOGICAL SPECIMENS I	Third cycle	EAK 529		1	8.00	8.00	Print

Description of course unit

Prerequisites and course requisities	No required
Language of instruction	Turkish
Coordinator	Prof.Dr. İbrahim Narin
Lecturer(s)	Prof.Dr. İbrahim Narin
Teaching assitant(s)	No
Mode of delivery	The emphasis of this course will be on theoretical information on the subject. Published up-to-date studies on extraction and analysis of some drugs will be investigated during the final lectures. At the end, the student will make a presentation
Course objective	n this course it is aimed to give the student an information on how to deal with biological materials and new types of drug analysis techniques in such materials. The extraction and analysis techniques in biological specimens will be taught
Course description	Separation and new analysis methods of drugs in biological specimens like urine, blood, hair, saliva, tissues and organs for industrial or forensic purposes or in pharmacokinetic studies.

Course contents

1	Why are the drugs analysed in biological materials? Gathering and storing specimens. Special problems with biological materials and drugs.
2	Conventional and new sample preparation techniques for bioanalysis
3	Analysis of drugs in biological specimens using GC and GC-MS techniques.
4	Analysis of drugs in biological specimens using GC and GC-MS techniques.
5	Immobilized Enzyme reactors in liquid chromatography
6	ICP-MS in bioanalysis and coupling with chromatographic applications, as an element specific detector
7	Exam
8	ICP-MS in bioanalysis and coupling with chromatographic applications, as an element specific detector
9	Regulations, compliance with GLP
10	Qualification and validation of the instruments and assays
11	Application of a validated analytical method
12	Application of a validated analytical method
13	Project presentation
14	Project presentation
15
16
17
18
19
20

Learning outcomes of the course unit

1	Learning biological specimen analysis and sample preparation techniques
2	Learning of ethical rules in biological samples
3	Classification of biological samples
4	Learning the properties of biological samples
5	Drug analysis in biological samples
6	Validation in biological samples
7
8
9
10

*Contribution level of the course unit to the key learning outcomes

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Number of stars refer to level of contribution from 1 (the least) to 5 (the most)

Planned learning activities, teaching methods and ECTS work load

	Quantity	Time (hour)	Quantity*Time (hour)
Lectures (face to face teaching)	14	3	42
Study hours out of classroom (study before and after the class)	10	5	50
Homework	2	16	32
Presentation / seminar	2	12	24
Quiz	0	0	0
Preparation for midterm exams	1	20	20
Midterm exams	1	1	1
Project (term paper)	0	0	0
Laboratuar	0	0	0
Field study	0	0	0
Preparation for final exam	1	28	28
Final exam	1	1	1
Research	0	0	0
Total work load			198
ECTS			8.00

Assessment methods and criteria

Evaluation during semester	Quantity	Percentage
Midterm exam	1	10
Quiz	0	0
Homework	2	30
Semester total		40
Contribution ratio of evaluation during semester to success		40
Contribution ratio of final exam to success		60
General total		100

Recommended and required reading

Textbook	Analysis of drugs in biological fluids, Joseph Chamberlein,1985
Additional references	1- Handbook of Analytical Separations, Volume 4, BioAnalytical Separations, Ian Wilson, 2003 2- Applications of LC-MS in Toxicology, Aldo Polettini, 2006 3- Published articles on Science Direct, on drug analysis in biological specimens (2000-2008

Files related to the course unit