Erciyes University - Info Package

Course unit title	Level of course unit	Course unit code	Type of course unit	Semester of course unit	Local credit	ECTS credit	Syllabus
PESTICIDE METABOLISM AND MODE OF ACTIONS	Third cycle	BİY 612		2	7.50	7.50	Print

Description of course unit

Prerequisites and course requisities	NON
Language of instruction	ENGLISH
Coordinator	PROF. DR. ABDURRAHMAN AYVAZ
Lecturer(s)	PROF. DR. ABDURRAHMAN AYVAZ
Teaching assitant(s)	NON
Mode of delivery	Face to face, through projection slides, text, animation and video presentation is given. Also drawing on the computer drawing program with the help and explanation of the mechanism
Course objective	Understand the mode of actions of the pesticides Understand the absorbtion, distribution, metabolism and excreation of the pesticides Teaching the factors that affects toxicity.
Course description	This course will provide an overview on insecticide classification, formulation, mode of action, resistance, metabolism, environmental fate, and regulatory legislation.Biochemical Aspects of Toxicology, Fundamentals of Toxicology and Dose-Response Relationships, Biomarkers, Criteria of Toxicity, New Technologies, Evaluation of Toxicity, Factors Affecting Toxic Responses, Factors Affecting Toxic Responses: Metabolism, Factors Affecting Metabolism and Disposition, Toxic Responses to Foreign Compounds, Direct Toxic Action: Tissue Lesions, Biochemical Mechanisms of Toxicity

Course contents

1	Biochemical Aspects of Toxicology
2	Fundamentals of Toxicology and Dose-Response Relationships
3	Factors Affecting Toxic Responses: Disposition
4	Absorption,Sites of Absorption, Distribution and Excretion
5	Factors Affecting Toxic Responses: Metabolism
6	Types of Metabolic Change, Phase 1 and Phase 2 Reactions
7	Factors Affecting Metabolism and Disposition
8	Chemical Factors Affecting Metabolism and Disposition
9	Biological Factors Factors Affecting Metabolism and Disposition
10	Toxic Responses to Foreign Compounds, Direct Toxic Action: Tissue Lesions
11	Mechanism and Response in Cellular Toxicity
12	Pharmacological, Physiological, and Biochemical Effects
13	Developmental Toxicology—Teratogenesis, Immunotoxicity, Genetic Toxicity, Chemical Carcinogenesis
14	Biochemical Mechanisms of Toxicity: Specific Examples
15	Biochemical Mechanisms of Toxicity: Specific Examples, Chemical Carcinogenesis Tissue Lesions: Liver Necrosis.
16	Tissue Lesions: Kidney Damage, Tissue Lesions: Lung Damage, Neurotoxicity, Exaggerated and Unwanted Pharmacological Effects,
17	Physiological Effects, Biochemical Effects: Lethal Synthesis and Incorporation, Biochemical Effects: Interaction with Specific Protein Receptors 361
18	Teratogenesis, Immunotoxicity, Multi-Organ Toxicity, Multi-Organ Toxicity: Metals
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Learning outcomes of the course unit

1	Students will learn that the disposition of a toxic compound in a biological system may be conveniently divided into four interrelated phasesş absorbtion, distrubition, metabolism and excreation
2	Students will learn that the metabolic fate of a compound can therefore have an important bearing on its toxic potential, disposition in the body, and eventual excretion.
3	They will learn the types of metabolic changes, phase 1 and phase 2 reactions
4	Students will have the knowladge that the metabolism of a xenobiotic will change its physicochemical properties, usually increasing water solubility, size, and molecular weight and therefore increasing excretion. They will also understand the consequences of metabolism are therefore a reduction in the biological half-life and hence exposure, a change in the nature and duration of biological activity, and a reduction in accumulation.
5	They will also learn the factors Affecting Metabolism and Disposition
6	The objective has always been to form a sound introduction to the basic principles of the subject from a biochemical and mechanistic viewpoint.
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*Contribution level of the course unit to the key learning outcomes

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Number of stars refer to level of contribution from 1 (the least) to 5 (the most)

Planned learning activities, teaching methods and ECTS work load

	Quantity	Time (hour)	Quantity*Time (hour)
Lectures (face to face teaching)	14	3	42
Study hours out of classroom (study before and after the class)	14	2	28
Homework	5	10	50
Presentation / seminar	2	4	8
Quiz	0	0	0
Preparation for midterm exams	1	20	20
Midterm exams	1	2	2
Project (term paper)	1	5	5
Laboratuar	0	0	0
Field study	0	0	0
Preparation for final exam	1	30	30
Final exam	1	2	2
Research	0	0	0
Total work load			187
ECTS			7.50

Assessment methods and criteria

Evaluation during semester	Quantity	Percentage
Midterm exam	1	60
Quiz	0	0
Homework	1	40
Semester total		100
Contribution ratio of evaluation during semester to success		40
Contribution ratio of final exam to success		60
General total		100

Recommended and required reading

Textbook	Principles of Biochemical Toxicology, John A. Timbrell Department of Pharmacy King’s College London London, UK.
Additional references	http://www.digitalbookindex.org/_search/search010agriculturepesticidesa.asp

Files related to the course unit